Structural Biology & Epigenetics

Our laboratory is interested in illustrating the molecular mechanisms of key biological events using the structural biology as a primary tool. Using both X-ray crystallography and cryogenic electron microscopy (cryo-EM), we aim to determine the atomic resolution structures of target macromolecules. We are currently interested in structural studies of (1) key epigenetic regulators in complex with its substrate – nucleosome, (2) human Sestrin2 and mTORC1 regulators, and (3) the method development in cryo-EM sample preparation.